CLSI Publishes Updated Protocols for Transferring Information Between Clinical Laboratory Instruments and Computer Systems
Wayne, Pennsylvania, USA—May 2008—Clinical and Laboratory Standards Institute (CLSI) has recently published an updated standard, Specification for Low-Level Protocol to Transfer Messages Between Clinical Laboratory Instruments and Computer Systems; Approved Standard—Second Edition (LIS01-A2), which describes the electronic transmission of digital information between clinical laboratory instruments (those that measure one or more parameters from one or multiple samples) and computer systems (those that are configured to accept instrument results for further processing, storage, reporting, or manipulation).
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CLSI Publishes Updated Standard for Broth Dilution Antifungal Susceptibility Testing of Yeasts
Wayne, Pennsylvania, USA—May 2008—Clinical and Laboratory Standards Institute (CLSI) has recently published an updated standard, Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts; Approved Standard—Third Edition (M27-A3), which addresses the selection and preparation of antifungal agents; implementation and interpretation of test procedures; and quality control (QC) requirements for susceptibility testing of yeasts that cause invasive fungal infections.
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CLSI Publishes Updated Reference Method for Broth Dilution Antifungal Susceptibility Testing of Filamentous Fungi
Wayne, Pennsylvania, USA—May 2008—With the increased incidence of systemic fungal infections and the growing number of antifungal agents, laboratory methods to guide the selection of antifungal therapy have gained greater attention. Clinical and Laboratory Standards Institute (CLSI) has recently published an updated standard, Reference Method for Broth Dilution Antifungal Susceptibility Testing of Filamentous Fungi; Approved Standard—Second Edition (M38-A2), which describes a method for testing the susceptibility of filamentous fungi (moulds) that cause invasive (Aspergillus spp., Fusarium spp., Rhizopus oryzae [R. arrhizus], Pseudallescheria boydii [Scedosporium apiospermum], S. prolificans, Sporothrix schenckii, and other opportunistic pathogenic moulds) and cutaneous (dermatophyte, Trichophyton, Microsporum, and Epidermophyton spp.) fungal infections to antifungal agents.
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New CLSI Guideline Provides Interpretive Criteria for Microorganism Identification by DNA Target Sequencing
Wayne, Pennsylvania, USA—May 2008—Because of the growing microbial diversity with emergence of common pathogens having rare or unique phenotypic characteristics and new pathogenic microorganisms with poorly defined phenotypes, conventional methods often cannot fully characterize bacterial or fungal isolates, and laboratories are now relying on broad-range DNA sequencing for microorganism identification.

Clinical and Laboratory Standards Institute (CLSI) has recently published a new document, Interpretive Criteria for Identification of Bacteria and Fungi by DNA Target Sequencing; Approved Guideline (MM18-A), which provides the most current information for microbial classification by gene sequencing, with particular emphasis on interpretation and reporting results. This document establishes guidelines for the systematic approach to classify bacteria and fungi by broad-range DNA sequencing.
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