Call for Nominations
Assessment of the Clinical Accuracy of Laboratory Tests Using Receiver Operation Characteristic (ROC) Plots

Clinical and Laboratory Standards Institute’s Area Committee on Evaluation Protocols has requested nominations to serve as subcommittee members to revise the CLSI guideline described below: 

PROJECT: 
(Revision of Approved Document) Assessment of the Clinical Accuracy of Laboratory Tests Using Receiver Operation Characteristic (ROC) Plots; Approved Guideline  (GP10-A)

Description:
GP10-A, which was reaffirmed in 2001, provides a protocol for evaluating the accuracy of a test to discriminate between two subclasses of subjects where there is some clinically relevant reason to separate them. In addition to the use of ROC plots, the importance of defining the question, selecting the sample group, and determining the “true” clinical state are emphasized.  In revising GP10 consideration will be given to expanding the guideline to address multiple analytes and changing the title to Assessment of the Clinical Accuracy of Diagnostic Tests Using Receiver Operation Characteristic (ROC) Plots.

Specific Expertise/Work Experience Needed: 
* Laboratorians with significant experience/expertise in performing and assuring quality of in vitro diagnostic assays.
* IVD manufacturers of clinical laboratory assay reagents and test systems
* Representatives of government agencies responsible for reviewing manufacturers' data for clearance or approval of clinical laboratory assay reagents and test systems.
* Statistical background and experience with ROC plots.

Review the objective of the project revision, and the requested volunteer expertise, and submit a nomination.

The deadline to submit the nomination form, including a curriculum vitae and disclosure of interests form, is 3 April 2006.  Send to Clinical and Laboratory Standards Institute, 940 West Valley Road, Suite 1400, Wayne, PA 19087.

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